The Tuberculosis, HIV, and Selenium Feedback Loop
Understanding the tuberculosis-HIV-selenium-deficiency positive feed-back loop is critical to fully understanding both tuberculosis and HIV disease. HIV, tuberculosis, co-infection with hepatitis and other opportunistic infections; plus selenium nutritional deficiency, form a multi-focal positive feedback loop that increases inflammatory and oxidative damage as it concurrently depletes the body’s selenium supply. This results in a decline in both immune competence and the antioxidant defenses selenium supports. In his book What Really Causes AIDS Harold Foster described this phenomenon as it relates to HIV alone as, “The Selenium-CD4 Cell Tailspin”. Monique van Lettow titled her book, “ Triple Trouble: Tuberculosis, HIV Infection and Malnutrition ”. Bemnet Amare referred to this as, the “Quadruple burden of HIV/AIDS, Tuberculosis, Chronic Inte...